Side Effects of Bosutinib
Common side effects in these studies included nausea, vomiting and diarrhea, which diminished over time. One abstract described the diarrhea as "self-limitiing". Lowered numbers of other blood cells, including platelets, white and red blood cells, were seen in one percent to nine percent of patients. There was also a buildup of fluid in the lungs and organs of 12 patients. But all of these symptoms were less severe than with other tyrosine kinase inhibitors.
One good thing about bosutinib is that it appears even patients with liver damage can tolderate it. Given that heptactic impairment poses such a problem for drug therapy, this is good news indeed. This drug leaves the body a few days after it is ingested.
Although the developers are looking at bosutinib mostly as a possible leukemia treatment, studies have also been launched to look at its efficacy in advanced and metastatic breast cancer as well as advanced or recurrent solid malignancies for which no other effective treatment was available.
Possible signs of leukemia include fever, feeling tired or fatigue, easy bruising or bleeding, shortness of breath, petechiae (flat, pinpoint spots under the skin due to bleeding), weight loss, loss of appetite, abnormal menstrual period in women, bleeding from the nose, bleeding gums, bone pain or tenderness and pale skin rashes or lesions. In diagnosing AML, doctors will perform a variety of tests and examine blood and bone marrow of the person. Some of the tests and procedures used include blood chemistry studies, complete blood count, peripheral blood smear, cytogenic analysis, bone marrow aspiration and biopsy, immunophenotyping and reverse transcription.