Anthracycline Drugs

Daunorubicin

Brand/Trade Names: Cerubidine, DaunoXome

Formula: C27H29NO10

Mechanism: Antimetabolite

Class: Antibiotic

Administration: Intraveneous

Notes:  First approved by the FDA in 1979.  Approved for treatment of acute lymphoblastic leukemia and acute myeloid leukemia.

Doxorubicin

Brand/Trade Names: Adriamycin, Rubex, Doxil

Formula: C27H29NO11

Mechanism: Antimetabolite

Class: Antibiotic

Administration: Intraveneous

Notes:  Called “the red devil” due to its bright red color and severe side effects.  First approved by the FDA in 1974.  Approved for treatment of acute lymphoblastic leukemia, acute myeloid leukemia, breast cancer, .stomach cancer, Hodgkin’s lymphoma, neuroblastoma, non-Hodgkin lymphoma, ovarian cancer, small cell lung cancer, soft tissue and bone sarcomas, thyroid cancer, bladder cancer, Wilms tumor.

Epirubicin

Brand/Trade Names: Ellence, Pharmorubicin

Formula: C27H29NO11

Mechanism: Antimetabolite

Class: Antibiotic

Administration: Intraveneous

Notes:  Approved by the FDA in 1999.  Approved for treatment of breast cancer.

Idarubicin

Brand/Trade Names: Idamycin

Formula: C26H28ClNO9

Mechanism: Antimetabolite

Class: Antibiotic

Administration: Intraveneous

Notes:  Approved by the FDA in 1990.  Approved for treatment of acute myeloid leukemia.

Valrubicin



Brand/Trade Names: Valstar

Formula: C34H36F3NO13

Mechanism: Antimetabolite

Class: Antibiotic

Administration: Intravenous

Notes:  Approved by the FDA in 1998.  Approved for treatment of bladder cancer.