Platinum Cancer Drugs

Also called platinum salts or metal salts. These are alkylating agents.

Cisplatin

Brand/Trade Names: Platinol, Cisplatinum, cis-diamminedichloroplatinum(II)

Formula:  H6Cl2N2Pt

Mechanism: Alkylating

Class: Platinum salt

Administration: Intraveneous

Notes: The “penicillin of cancer”. First used in the 1970s. One of the most widely used chemotherapy drugs.

Carboplatin

Brand/Trade Names: Paraplatin, cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)

Formula: C6H12N2O4Pt or C6H14N2O4Pt

Mechanism: Alkylating

Class: Platinum salt

Administration: Intraveneous

Notes: The second generation of platinum cancer drugs. Designed to have less severe side effects. Used for many of the same cancers and in similar regimens to cisplatin.

Oxaliplatin

Brand/Trade Names: Eloxatin, [(1R,2R)-cyclohexane-1,2-diamine](ethanedioato-O,O’)platinum(II)

Formula: C8H14N2O4Pt

Mechanism: Alkylating

Class: Platinum salt

Administration: Intraveneous

Notes: A third generation platinum chemotherapy agent. Sometimes considered second generation. Used for many of the same cancers and in similar regimens to cisplatin.