Platinum Cancer Drugs

Also called platinum salts or metal salts. These are alkylating agents.

Cisplatin

Brand/Trade Names: Platinol, Cisplatinum, cis-diamminedichloroplatinum(II)

Formula:  H6Cl2N2Pt

Mechanism: Alkylating

Class: Platinum salt

Administration: Intravenous

Notes: The “penicillin of cancer”. First used in the 1970s. Approved by the FDA in 1978.  One of the most widely used chemotherapy drugs.  Formally approved for bladder cancer, testicular cancer, and ovarian cancer, but often used off-label.

Carboplatin

Brand/Trade Names: Paraplatin, cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)

Formula: C6H12N2O4Pt or C6H14N2O4Pt

Mechanism: Alkylating

Class: Platinum salt

Administration: Intraveneous

Notes: The second generation of platinum cancer drugs. Designed to have less severe side effects. Used for many of the same cancers and in similar regimens to cisplatin.  Approved by the FDA in 1989 for ovarian cancer.

Oxaliplatin

Brand/Trade Names: Eloxatin, [(1R,2R)-cyclohexane-1,2-diamine](ethanedioato-O,O’)platinum(II)

Formula: C8H14N2O4Pt

Mechanism: Alkylating

Class: Platinum salt

Administration: Intravenous

Notes: A third generation platinum chemotherapy agent. Sometimes considered second generation. Approved by the FDA in 2004 for colorectal cancer.