Hormone Suppressants for Cancer Treatment

Abiraterone

Brand/Trade Names: Zytiga

Formula: C24H31NO

Mechanism: Hormone Suppressant

Class: Antiandrogen, Pyridine

Administration: Oral

Notes:

Apalutamide

Brand/Trade Names: Erleada

Formula: C21H15F4N5O2S

Mechanism: Hormone Suppressant

Class:

Administration: Oral

Notes:

Bicalutamide

Brand/Trade Names: Casodex

Formula: C18H14F4N2O4S

Mechanism: Hormone Suppressant

Class: Anti-Androgen, Nitrile

Administration: Oral

Notes:

Degarelix

Brand/Trade Names: Firmagon

Formula: C84H107ClN18O18

Mechanism: Hormone Suppressant

Class: Gonadotropin-releasing hormone antagonistm, GRH antagonist

Administration: Oral

Notes:

Estramustine

Brand/Trade Names: Emcyt

Formula: C23H31Cl2NO3

Mechanism: alkylating agent

Class: mustard

Administration: Oral

Notes: Estrogen ester, conjugated with estradiol, used for advanced prostate cancer

Enzalutamide

Brand/Trade Names: Xtandi

Formula: C21H16F4N4O2S

Mechanism: Anti-androgen

Class: Hormone Suppressant

Administration: Oral

Notes:

Goserelin

Brand/Trade Names: Zoladex

Formula: C59H84N18O14

Mechanism: Hormone Suppressant

Class: Gonadotropin-releasing hormone antagonist (GRH antagonist)

Administration: Oral

Notes: Used against breast and prostate cancer

Leuprolide

Brand/Trade Names: Viadur, Eligard

Formula: C59H84N16O12

Mechanism: Luteinizing hormone releasing hormone agonist

Class: Hormone

Administration: Intravenous

Notes:

Mitotane

Brand/Trade Names: Lysodren

Formula: C14H10Cl4

Mechanism: inhibitor of the adrenal cortex

Class: hormone therapy

Administration: Oral, three or four divided doses per day.

Notes:

Nilutamide

Brand/Trade Names: Nilandron, Anandron

Formula: C12H10F3N3O4

Mechanism:

Class: Hormone

Administration: Oral

Notes:

Megestrol

Brand/Trade Names: Megace

Formula: C24H32O4

Mechanism:

Class: Hormone

Administration: Oral

Notes:

Octreotide

Brand/Trade Names: Sandostatin

Formula: C49H66N10O10S2

Mechanism:

Class: hormone

Administration: Intravenous, subcutaneous

Notes:

Toremifene

Brand/Trade Names: Fareston

Formula: C26H28ClNO

Mechanism:

Class: hormone

Administration: Oral

Notes:

Triptorelin

Brand/Trade Names: Decapeptyl, Gonapeptyl

Formula: C64H82N18O13

Mechanism:

Class: Hormone

Administration: Intravenous

Notes:

Fulvestrant

Brand/Trade Names: Faslodex

Formula: C32H47F5O3S

Mechanism:

Class: hormone

Administration: Injection to muscle

Notes:

Histrelin

Brand/Trade Names: Vantas, Supprelin LA

Formula: C66H86N18O12

Mechanism:

Class: hormone

Administration: intramuscular injection, subcutaneous implant

Notes:

Flutamide

Brand/Trade Names: Eulexin

Formula: C11H11F3N2O3

Mechanism: anti-androgen

Class: Hormone Suppressant

Administration: Oral

Notes:

Tamoxifen

Brand/Trade Names: Nolvadex

Formula: C26H29NO

Mechanism: anti-estrogen

Class: Hormone Suppressant

Administration: Oral

Notes: Tamoxifen and contralateral breast cancer (CBC) risk for BRCA1 and BRCA2 mutation carriers