Inhibitor Drugs

Afatinib

Brand/Trade Names: Gilotrif

Formula: C24H25ClFN5O3

Mechanism: Tyrosine Kinase Inhibitor

Class:

Administration: Oral

Notes: EGFR inhibitor

Axitinib

Brand/Trade Names: Inlyta

Formula: C22H18N4Osub>S

Mechanism: Tyrosine Kinase Inhibitor

Class:

Administration: Oral

Notes: VEGF inhibitor and angiogenesis inhibitor.

Cabozantinib

Brand/Trade Names: Cometriq

Formula: C28H24FN3O5

Mechanism: Tyrosine Kinase Inhibitor

Class:

Administration: Oral

Notes:

Osimertinib

Brand/Trade Names: Tagrisso, Mereletinib

Formula: C28H33N7O2

Mechanism: tyrosine kinase inhibitor

Class:

Administration: Oral

Notes: EGFR inhibitor

Ponatinib

Brand/Trade Names: Iclusig

Formula: C29H27F3N6O

Mechanism: tyrosine kinase inhibitor

Class:

Administration: Oral

Notes:

Lenvatinib

Brand/Trade Names: Lenvima

Formula: C21H19ClN4O4

Mechanism: tyrosine kinase inhibitor

Class:

Administration: Oral

Notes:

Midostaurin

Brand/Trade Names: Rydapt

Formula: C35H30N4O4

Mechanism: tyrosine kinase inhibitor

Class:

Administration: Oral

Notes: FLT3 inhibitor

Neratinib

Brand/Trade Names: Neratinib

Formula: C30H29ClN6O3

Mechanism: tyrosine kinase inhibitor

Class:

Administration: Oral

Notes:

Regorafenib

Brand/Trade Names: Stivarga

Formula: C21H17ClF4N4O4

Mechanism: tyrosine kinase inhibitor

Class:

Administration: Oral

Notes:

Vandetanib

Brand/Trade Names: Caprelsa

Formula: C22H24BrFN4O2

Mechanism: Tyrosine Kinase Inhibitor

Class:

Administration: Oral

Notes: EGFR and VEGFR inhibitor

Vismodegib

Brand/Trade Names: Erivedge

Formula: C19H14Cl2N2O3S

Mechanism: Tyrosine Kinase Inhibitor

Class:

Administration: Oral

Notes:

Ziv-aflibercept

Brand/Trade Names: Zaltrap

Formula: C4318H6788N1164O1304S32

Mechanism: VEGF inhibitor

Class: MAB

Administration: Intraveneous

Notes:

Venetoclax

Brand/Trade Names: Venclexta

Formula: C45H50ClN7O7S

Mechanism: BCL-2 Inhibitor

Class:

Administration: Oral

Notes:

Dasatinib

Brand/Trade Names: SPRYCEL

Formula: C22H26ClN7O2S

Mechanism: Tyrosine Kinase Inhibitor

Class:

Administration: Oral

Notes: Pretty much used only to treat leukemia.

Erlotinib

Brand/Trade Names: Tarceva

Formula: Csub>22H23N3O4

Mechanism: EGFR inhibitor

Class:

Administration: Oral

Notes: Used to treat non-small cell lung cancer and pancreatic cancer.

Erlotinib

Brand/Trade Names: Tarceva

Formula: C22H23N3O4

Mechanism: EGFR inhibitor

Class:

Administration: Oral

Notes: Not used as often as it once was, as newer drugs have displaced it. More on gefitinib.

Gefitinib

Brand/Trade Names: Iressa

Formula: C22H24ClFN4O3

Mechanism: EGFR inhibitor

Class:

Administration: Oral

Notes: Not used as often as it once was, as newer drugs have displaced it. More on gefitinib.

Imatinib

Brand/Trade Names: Gleevec, Glivec

Formula: C29H31N7O

Mechanism:

Class:

Administration: Oral

Notes: Blocks the protein made by the bcr/abl oncogene

Lapatinib

Brand/Trade Names: Tykerb, Tyverb

Formula: C29H26ClFN4O4S

Mechanism: Kinase Inhibitor

Class:

Administration: Oral

Notes: Used against advanced breast cancer, often after other medicines have been tried.

Nilotinib

Brand/Trade Names: Tasigna

Formula: C28H22F3N7O

Mechanism: Kinase Inhibitor

Class:

Administration: Oral

Notes: FDA-approved to treat chronic myelogenous leukemia. More on nilotinib.

Pazopanib

Brand/Trade Names: Votrient

Formula: C21H23N7O2S

Mechanism: Kinase Inhibitor

Class:

Administration: Oral

Notes: Approved for advanced renal cell carcinoma. Can cause liver damage. More.

Sorafenib

Brand/Trade Names: Nexavar

Formula: C21H16ClF3N4O3

Mechanism: Kinase Inhibitor

Class:

Administration: Oral

Notes: Approved for certain types of liver and kidney cancer.

Sunitinib

Brand/Trade Names: Sutent

Formula: C22H27FN4O2

Mechanism: Kinase Inhibitor

Class:

Administration: Oral

Notes: Employed against several hard-to-treat cancers.

Proteasome inhibitors

Bortezomib

Brand/Trade Names: Velcade

Formula: C19H25BN4O4

Mechanism: proteasome inhibitor

Class:

Administration: Intraveneous

Notes: The first approved proteasome inhibitor for cancer treatment, it has a boron atom in its molecule.

Carfilzomib

Brand/Trade Names: Kyprolis

Formula: C40H57N5O7

Mechanism: proteasome inhibitor

Class:

Administration: Intraveneous

Notes: Derivative of epoxomicin, which is extracted from bacteria.

Ixazomib

Brand/Trade Names: Ninlaro

Formula: C14H19Cl2N2O4

Mechanism:

Class:

Administration:

Notes:

Enasidenib

Brand/Trade Names: Idhifa

Formula: C19H17F6N7O

Mechanism: IDH2 inhibitor

Class:

Administration: Oral

Notes:

Idelalisib

Brand/Trade Names: Zydelig

Formula: C22H18FN7O

Mechanism: Phosphatidylinositol 3-kinase inhibitor

Class:

Administration: Oral

Notes:


Mechanism: proteasome inhibitor

Class:

Administration: Oral

Notes: Like bortezomib, the molecule contains a boron atom.

BTK Inhibitors

Ibrutinib

Brand/Trade Names: Imbruvica

Formula: C25H24N6O2

Mechanism: Bruton’s tyrosine kinase inhibitor

Class:

Administration: Oral

Notes:

Acalabrutinib

Brand/Trade Names: Calquence

Formula: C26H23N7O2

Mechanism: Bruton’s tyrosine kinase inhibitor

Class:

Administration: Oral

Notes:

CDK Inhibitors

Ribociclib

Brand/Trade Names: Kisqali

Formula: C23H30N8O

Mechanism: Cyclin-dependent kinase inhibitor

Class:

Administration: Oral

Notes:

Palbociclib

Brand/Trade Names: Ibrance

Formula: C24H29N7O2

Mechanism: Cyclin-dependent kinase inhibitor

Class:

Administration: Oral

Notes:

Abemaciclib

Brand/Trade Names: Verzenio

Formula: C27H32F2N8

Mechanism: Cyclin-dependent kinase inhibitor

Class:

Administration: Oral

Notes:

BRAF Inhibitors

Vemurafenib

Brand/Trade Names: Zelboraf

Formula: C23H18ClF2N3O3S

Mechanism: B-Raf enzyme inhibitor

Class:

Administration: Oral

Notes:

Encorafenib

Brand/Trade Names: Braftovi

Formula: C22H27ClFN7O4S

Mechanism: BRAF Inhibitor

Class:

Administration: Intraveneous

Notes:

Dabrafenib

Brand/Trade Names: Tafinlar

Formula: C23H20F3N5O2S2

Mechanism: BRAF Inhibitor

Class:

Administration: Oral

Notes:

MEK Inhibitors

Medicines that inhibit mitogen-activated protein kinase kinase enzymes

Trametinib

Brand/Trade Names: Mekinist

Formula: C26H23FIN5O4

Mechanism: MEK1 and MEK2 inhibitor

Class:

Administration: Oral

Notes: Approved to treat BRAF-mutated melanoma

Cobimetinib

Brand/Trade Names: Cotellic

Formula: C21H21F3IN3O2

Mechanism: MEK inhibitor

Class:

Administration: Oral

Notes: Given in combination with vemurafenib

Binimetinib

Brand/Trade Names: Mektovi

Formula: C17H15BrF2N4O3

Mechanism: MEK Inhibitor

Class:

Administration: Oral

Notes:

ALK Inhibitors

Medicines that inhibit receptors of tyrosine kinase anaplastic lymphoma kinase (ALK),

Crizotinib

Brand/Trade Names: Xalkori

Formula: C21H22Cl2FN5O

Mechanism: ALK Inhibitor

Class:

Administration: Oral

Notes:

Ceritinib

Brand/Trade Names: Zykadia

Formula: C28H36ClN5O3S

Mechanism: ALK Inhibitor

Class:

Administration: Oral

Notes:

Alectinib

Brand/Trade Names: Alecensa

Formula: C30H34N4O2

Mechanism: ALK Inhibitor

Class:

Administration: Oral

Notes: