Inhibitor Drugs

Bortezomib

Other generic names:
Forumla:
C19H25BN4O4
Trade names
Velcade
Class (action)
Class (chemical)
Proteasome Inhibitor Dipeptide
Administration
Intravenous
Notes
A rare drug that is a compound of boron. More on bortezomib.

Crizotinib

Other generic names:
Forumla:
C21H22Cl2FN5O
Trade names
Class (action)
Class (chemical)
ALK Inhibitor Kinase Inhibitor
Administration
Oral
Notes
Approved by FDA in 2011 for ALK-positive lung cancer.

Dasatinib

Other generic names:
Forumla:
C22H26ClN7O2S
Trade names
Sprycel
Class (action)
Class (chemical)
Kinase Inhibitor Kinase Inhibitor
Administration
Oral
Notes
Pretty much used only to treat leukemia.

Erlotinib

Other generic names:
Forumla:
Erlotinib hydrochloride C22H23N3O4
Trade names
Tarceva
Class (action)
Class (chemical)
EGFR inhibitor Kinase Inhibitor
Administration
Oral
Notes
Used to treat non-small cell lung cancer and pancreatic cancer.

Gefitinib

Other generic names:
Forumla:
C22H24ClFN4O3
Trade names
Iressa
Class (action)
Class (chemical)
EGFR inhibitor Kinase Inhibitor
Oral
Oral
Notes
Not used as often as it once was, as newer drugs have displaced it.

Imatinib

Other generic names:
Forumla:
Imatinib mesilate C29H31N7O
Trade names
Gleevec, Glivec
Class (action)
Class (chemical)
Kinase Inhibitor Kinase Inhibitor
Administration
Intravenous
Notes
Blocks the protein made by the bcr/abl oncogene

Lapatinib

Other generic names:
Forumla:
Lapatinib Ditosylate C29H26ClFN4O4S
Trade names
Tykerb, Tyverb
Class (action)
Class (chemical)
Kinase Inhibitor Kinase Inhibitor
Administration
Oral
Notes
Used against advanced breast cancer, often after other medicines have been tried.

Nilotinib

Other generic names:
Forumla:
C28H22F3N7O
Trade names
Tasigna
Class (action)
Class (chemical)
Kinase Inhibitor Kinase Inhibitor
Administration
Oral
Notes
FDA-approved to treat chronic myelogenous leukemia.

Pazopanib

Other generic names:
Forumla:
C21H23N7O2S
Trade names
Votrient
Class (action)
Class (chemical)
Kinase Inhibitor Kinase Inhibitor
Administration
Oral
Notes
Approved for advanced renal cell carcinoma. Can cause liver damage.  More.

Sorafenib

Other generic names:
Forumla:
Sorafenib tosylate C21H16ClF3N4O3
Trade names
Nexavar
Class (action)
Class (chemical)
Kinase Inhibitor Kinase Inhibitor
Administration
Oral
Notes
Approved for certain types of liver and kidney cancer.

Sunitinib

Other generic names:
Forumla:
SU11248, Sunitinib Malate C22H27FN4O2
Trade names
Sutent
Class (action)
Class (chemical)
Kinase Inhibitor Kinase Inhibitor
Oral
Oral
Notes
Employed against several hard-to-treat cancers.

Temsirolimus

Notes

Other generic names:
Forumla:
CCI-779 C56H87NO16
Trade names
Torisel
Class (action)
Class (chemical)
mTOR Inhibitor mTOR Inhibitor
Administration
Intravenous
FDA-approved for treatment of advanced renal cell carcinoma.