Mustards

Cyclophosphamide

Brand/Trade Names: Cytoxan, Neosar, Endoxan, Cytophosphane

Formula: C7H15Cl2N2O2P

Mechanism: Alkylating

Class: Mustard

Administration: Intravenous, oral

Notes: Prodrug that converts to active drug inside the body.  Approved by the FDA in 1959.  Used for treatment of Ovarian cancer, Retinoblastoma, Chronic myelogenous leukemia, Hodgkin’s disease, Multiple myeloma, Mycosis fungoides, Neuroblastoma, Non-Hodgkin lymphoma, Acute lymphoblastic leukemia,  Acute monocytic leukemia, Acute myeloid leukemia, Breast cancer, Chronic granulocytic leukemia. and Chronic lymphocytic leukemia

Chlorambucil

Brand/Trade Names: Leukeran

Formula: C14H19Cl2NO2

Mechanism: Alkylating

Class: Mustard

Administration: Intravenous, oral

Notes:  Approved by FDA in 1957.  Used in treatment of Chronic lymphocytic leukemia, Hodgkin’s disease., and Non-Hodgkin’s lymphoma .

Mechlorethamine

Brand/Trade Names: Mustargen, Mechlorethamine Hydrochloride, mustine, nitrogen mustard, and HN2

Formula: C5H11Cl2N

Mechanism: Alkylating

Class: Mustard

Administration: Intravenous, topical

Notes:  Approved by the FDA in 2013.  Used for Bronchogenic carcinoma, Chronic lymphocytic leukemia, Chronic myelogenous leukemia,
Hodgkin’s disease. Malignant pleural effusion, malignant pericardial effusion, malignant peritoneal effusion, Mycosis fungoides, and Non-Hodgkin’s lymphoma

Bendamustine

Brand/Trade Names: Ribomustin, Treanda, and 4-[5-[Bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid,

Formula: C16H21Cl2N3O2

Mechanism: Alkylating

Class: Mustard

Administration: Intraveneous

Notes:  First approved by the FDA in 2008.  More. Used for treatment of B-cell non-Hodgkin lymphoma and Chronic lymphocytic leukemia.

Estramustine

Brand/Trade Names: Emcyt, Estracit

Formula: C23H31Cl2NO3

Mechanism: Alkylating

Class: Mustard

Administration: Oral

Notes:  Approved by the FDA in 1981.