Side effects of Nilotinib

Nilotinib is better tolerated than most anti-cancer drugs. It has side effects, but all drugs have potential side effects in some people. It is particularly recognized for not suppressing red blood cell production the way many chemotherapy drugs do. Nilotinib is well tolerated even over long periods of use.

Nilotinib may cause QTc prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death). This information comes from the federal government's MedlinePlus website on Nilotinib.

Possible side effects include:

  • rash
  • itching
  • nausea
  • vomiting
  • diarrhea
  • constipation
  • heartburn
  • gas
  • loss of appetite
  • headache
  • dizziness
  • tiredness
  • difficulty falling asleep or staying asleep
  • night sweats
  • muscle cramps
  • back, bone, joint, limb, or muscle pain
  • hair loss
  • dry or reddened skin
  • numbness, burning, or tingling in the hands or feet

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

  • unexplained bleeding or bruising
  • blood in urine or stool
  • unexplained weakness
  • fever, sore throat, chills, or other signs of infection
  • shortness of breath
  • swelling of hands, ankles, feet, or face
  • sudden stomach area pain
  • yellowing of the skin and eyes

The FDA requires nilotinib to have a "black box" warning for possible heart problems.

There are concerns that nilotinib leads to, or is associated with, interstitial lung disease.

 

 


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