Antifolates

Pralatrexate

Brand/Trade Names: Folotyn

Formula: C23H23N7O5

Mechanism: Antimetabolite

Class: Antifolate

Administration: Intravenous

Notes:  Approved by the FDA in 2009.

Pemetrexed

Brand/Trade Names: Alimta

Formula: C20H21N5O6

Mechanism: Antimetabolite

Class: Antifolate

Administration: Intravenous

Notes:  Approved by the FDA in 2004.

Methotrexate

Brand/Trade Names: MTX, amethopterin

Formula: C20H22N8O5

Mechanism: Antimetabolite

Class: Antifolate

Administration: Intravenous

Notes: Very widely used.  First approved by the FDA in 1953.

methotrexate molecule