Platinum Cancer Drugs

Also called platinum salts or metal salts. These are alkylating agents.  Cisplatin is one of the most widely used chemotherapy medicines.  Carboplatin is considered a second-generation platinum agent, designed to have less severe side effects.  Oxaliplatin is sometimes called a third-generation agent, although some classify it as a second-generation agent.

Cisplatin

Brand/Trade Names: Platinol, Cisplatinum, cis-diamminedichloroplatinum(II)

Formula:  H6Cl2N2Pt

Mechanism: Alkylating

Class: Platinum salt

Administration: Intravenous

Notes: The “penicillin of cancer”. Approved by the FDA in 1978.  One of the most widely used chemotherapy drugs.  Formally approved for bladder cancer, testicular cancer, and ovarian cancer, but often used off-label.

Carboplatin

Brand/Trade Names: Paraplatin, cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)

Formula: C6H12N2O4Pt or C6H14N2O4Pt

Mechanism: Alkylating

Class: Platinum salt

Administration: Intravenous

Notes: Approved by the FDA in 1989.   Used for ovarian cancer and many of the same cancers and in similar regimens to cisplatin.  

Oxaliplatin

Brand/Trade Names: Eloxatin, [(1R,2R)-cyclohexane-1,2-diamine](ethanedioato-O,O’)platinum(II)

Formula: C8H14N2O4Pt

Mechanism: Alkylating

Class: Platinum salt

Administration: Intravenous

Notes: Approved by the FDA in 2004.  Used for treatment of colorectal cancer.