Hormone Suppressants for Cancer Treatment

Abiraterone

Brand/Trade Names: Zytiga

Formula: C24H31NO

Mechanism: Hormone Suppressant, CYP17A1 inhibitor

Class: Antiandrogen, Pyridine

Administration: Oral

Notes:  Approved by the FDA in 2011.  Used for treatment of prostate cancer.

Apalutamide

Brand/Trade Names: Erleada

Formula: C21H15F4N5O2S

Mechanism: Hormone Suppressant

Class:

Administration: Oral

Notes:  Approved by the FDA in 2018.  Used for treatment of prostate cancer.

Bicalutamide

Brand/Trade Names: Casodex

Formula: C18H14F4N2O4S

Mechanism: Hormone Suppressant

Class: Anti-Androgen

Administration: Oral

Notes: Approved by the FDA in 1995.  Used for treatment of prostate cancer.

Darolutamide

Brand/Trade Names: Nubeqa

Formula: C19H19ClN6O2

Mechanism: Hormone Suppressant

Class: Anti-androgen

Administration: Oral

Notes: Approved by the FDA in 2019.  Used in treatment of prostate cancer.

Degarelix

Brand/Trade Names: Firmagon

Formula: C84H107ClN18O18

Mechanism: Hormone Suppressant

Class: Gonadotropin-releasing hormone antagonist

Administration: Oral

Notes: Approved by the FDA in 2008.  Used for treatment of prostate cancer.

Estramustine

Brand/Trade Names: Emcyt

Formula: C23H31Cl2NO3

Mechanism: alkylating agent

Class: mustard

Administration: Oral

Notes: Estrogen ester, conjugated with estradiol, used for advanced prostate cancer.  Approved by the FDA in 1981.

Enzalutamide

Brand/Trade Names: Xtandi

Formula: C21H16F4N4O2S

Mechanism: Anti-androgen

Class: Hormone Suppressant

Administration: Oral

Notes:  Approved by the FDA in 2012.   Used for treatment of prostate cancer.

Goserelin

Brand/Trade Names: Zoladex

Formula: C59H84N18O14

Mechanism: Lowers estrogen level in body

Class: Luteinizing hormone releasing hormone agonist.  Sometimes called Gonadotropin-releasing hormone antagonist (GnRH antagonist)

Administration: Subcutaneous (injection under skin)

Notes: Approved by the FDA in 1989.  Used for treatment of breast and prostate cancer.

Leuprolide

Brand/Trade Names: Viadur, Eligard

Formula: C59H84N16O12

Mechanism: Lowers estrogen level in body

Class: Luteinizing hormone releasing hormone agonist.  Sometimes called Gonadotropin-releasing hormone antagonist (GnRH antagonist)

Administration: Subcutaneous (injection under skin)

Notes:  Approved by the FDA in 1985.  Used in treatment of prostate, breast, ovarian, and uterine cancer.

Mitotane

Brand/Trade Names: Lysodren

Formula: C14H10Cl4

Mechanism: inhibitor of the adrenal cortex

Class: hormone therapy

Administration: Oral, three or four divided doses per day.

Notes:  Approved by the FDA in 1970.  Used in treatment of adrenocortical carcinoma.

Nilutamide

Brand/Trade Names: Nilandron, Anandron

Formula: C12H10F3N3O4

Mechanism:

Class: Hormone

Administration: Oral

Notes:  Approved by the FDA in 1996.  Used in treatment of prostate cancer.

Megestrol

Brand/Trade Names: Megace

Formula: C24H32O4

Mechanism:

Class: Hormone

Administration: Oral

Notes:  Approved by the FDA in 1971.

Octreotide

Brand/Trade Names: Sandostatin

Formula: C49H66N10O10S2

Mechanism:

Class: hormone analog

Administration: Intravenous, subcutaneous

Notes:  Approved by the FDA in 1988.  Used for treatment of cancerous tumors that secrete growth hormone. Doesn’t directly attack cancer, but helps with side effects when other therapy attacks cancer.

Relugolix

Brand/Trade Names: Orgovyx

Formula: C29H27F2N7O5S

Mechanism:

Class: hormone suppressant

Administration: Oral

Notes:  Approved by the FDA in 2020.  Used for treatment of prostate cancer.

Toremifene

Brand/Trade Names: Fareston

Formula: C26H28ClNO

Mechanism:

Class: Hormone suppressant (anti-estrogen)

Administration: Oral

Notes:  Approved by the FDA in 1997.  Used for treatment of breast cancer.

Triptorelin

Brand/Trade Names: Decapeptyl, Gonapeptyl

Formula: C64H82N18O13

Mechanism:

Class: Hormone

Administration: Intravenous

Notes:  Approved by the FDA in 2017.  Used in treatment of prostate cancer.

Fulvestrant

Brand/Trade Names: Faslodex

Formula: C32H47F5O3S

Mechanism:

Class: hormone

Administration: Injection to muscle

Notes:  Approved by the FDA in 2002.  Used in treatment of breast cancer.

Histrelin

Brand/Trade Names: Vantas, Supprelin LA

Formula: C66H86N18O12

Mechanism:

Class: hormone

Administration: intramuscular injection, subcutaneous implant

Notes:  Approved by the FDA in 2004.

Flutamide

Brand/Trade Names: Eulexin

Formula: C11H11F3N2O3

Mechanism: Anti-androgen

Class: Hormone Suppressant

Administration: Oral

Notes:  Approved by the FDA in 1989.  Used for treatment of prostate cancer.

Tamoxifen

Brand/Trade Names: Nolvadex

Formula: C26H29NO

Mechanism: anti-estrogen

Class: Selective estrogen receptor modulator

Administration: Oral

Notes: Approved by the FDA in 1979.  Used in treatment of breast cancer.