Taxanes

These medicines are active in the M-Phase.  In the nucleus of the dividing cell they bind to the microtubules and stop reproduction.  Scientists call these cytoskeletal disruptors or microtubule-targeting agents.  The name taxane comes from taxus, which is a genus of tree (the yew trees).  Three taxanes are approved in the US for cancer treatment.

In addition to taxanes, other natural substances used in chemotherapy include trabectedin and the vinca alkaloids.

Paclitaxel

Brand/Trade Names: Taxol, Abraxane

Formula: C₄₇H₅₁NO₁₄

Mechanism: Mitotic Inhibitor

Class: Taxane

Administration: Intraveneous

Notes: First discovered in the bark of the Pacific Yew tree.  Now made by biotechnology.  One of the most famous chemo drugs.  Often paired with other medicines as part of combination chemotherapy.  First approved by the FDA in 1992.   Used in treatment of breast, ovarian, lung, bladder, prostate, melanoma, esophageal cancers.   More on this medicine.

Docetaxel

Brand/Trade Names: Taxotere

Formula: C₄₃H₅₃NO₁₄

Mechanism: Mitotic Inhibitor

Class: Taxane

Administration: Intraveneous

Notes: Similar to paclitaxel.  First approved by the FDA in 1996.  Used in treatment of breast, prostate, stomach cancer, non-small cell lung cancer, head and neck cancer.

Cabazitaxel

Brand/Trade Names: Jevtana

Formula: C₄₅H₅₇NO₁₄

Mechanism: Anti-microtubule agent

Class: Taxane

Administration: Intravenous

Notes:  Approved by the FDA in 2010.  Used in treatment of prostate cancer.